Pre-formulation & Formulation Aspects
The physio-chemical and mechanical properties of the drug are indispensable in the preparation of the drug in pre-formulation studies. In dealing with protein pre-formulation, it is important to consider the solution behavioral of a given protein under different physiological conditions. While formulating the drug, physio-chemical properties like particle size, polymorphism`, pH and solubility are should be taken into consideration as they impact bio availability and the activity of a drug. The formulation should ensure that the dosage should have a uniform appearance, acceptable taste and capsule disintegration properties.